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Functional Assessment of Urinary Neuro-biogenic Amines—A COMPREHENSIVE GUIDE 

89

may be associated with stress

response

5-HT

7

receptors

increase neuron excitability

studies indicate 5-HT

7

mediates the

relaxation of smooth muscle in GI

tract and cardiovascular system

may regulate circadian rhythms

and sleep

may be associated with depression,

schizophrenia, cognition, sleep,

epilepsy

The serotonin signaling system may

be affected by antihypertensive, antide-

pressant, anti-anxiety and anti-psychot-

ic medications. These medications act

upon one or more of the 5-HT receptors.

Consider:

Essential precursor Tryptophan

status

( Plasma

or

Urine Amino Acids

)

Gastrointestinal function

( Comprehensive Stool Analysis

)

Glutathione status

( Glutathione; erythrocytes )

Bacterial lipopolysaccharide (LPS)

( Intestinal Permeability Test

)

Oxidative stress

( DNA Oxidative Damage Assay/8-OHdG )

MAOA or COMT SNPs

( DNA Methylation Pathway )

References:

Barnes, Nicholas M. and Neumaier, John F.

(2011)

Neuronal 5-HT Receptors and SERT

University of Birmingham Medical School

Bauer, M.; Heinz, A.; Whybrow, P.C.(2002)

Thyroid hormones, serotonin and mood:

of synergy and significance in the adult

brain

Nature Publishing Group

vol. 7 (2)

Cansev, M.; Wurtman, R.J. (2007) Chapter 4

Aromatic Amino Acids in the Brain

Handbook of Neurochemistry and Molecular

Neurobiology

Springer, US.

De Maeyer, J H; Lefebvre, R A; Schuurkes, J

A J (2008)

5-HT4 receptor agonists: similar but not the

same.

Neurogastroenterology and motility : the official

journal of the European Gastrointestinal

Motility Society

vol. 20 (2) p. 99-112

Field, Tiffany; Hernandez-Reif, Maria; Diego,

Miguel; Schanberg, Saul; Kuhn, Cynthia

(2009)

CORTISOL DECREASES AND

SEROTONIN AND DOPAMINE

INCREASE FOLLOWING MASSAGE

THERAPY

Informa UK Ltd UK

Field, Tiffany; Diego, Miguel; Hernandez-

Reif, Maria; Figueiredo, Barbara; Deeds,

Osvelia et al. (2008)

Prenatal serotonin and neonatal outcome:

brief report.

Infant behavior & development vol. 31 (2)

p. 316-20

Fink, Klaus B. and Göthert, Manfred. (2007)

5-HT Receptor Regulation of

Neurotransmitter Release

Pharmacological Reviews December 2007

vol. 59 no. 4 360-417

Fukui, Michiaki; Tanaka, Muhei; Toda,

Hitoshi; Asano, Mai; Yamazaki, Masahiro

et al. (2012)

High plasma 5-hydroxyindole-3-acetic acid

concentrations in subjects with metabolic

syndrome.

Diabetes care

vol. 35 (1) p. 163-7

Gershon, Michael D (2013)