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50

 Functional Assessment of Urinary Neuro-biogenic Amines—A COMPREHENSIVE GUIDE

precursor), B vitamins and

calcium-D-glucarate

– The amino acids glutamine,

glycine, and taurine are used

in Phase II conjugation

Phase III detoxification occurs

when the metabolized xenobiotic

is transported out of the cell for

excretion in urine or bile. Phase III

efflux pumps require ATP. Nutrients

that may support phase III include

B vitamins, magnesium, manganese,

iron, and CoQ10.

Red Blood Cell (RBC) Elements

A diet rich in fruits, vegetables and

healthy (omega-3) fats will also support

liver functions. Liver phase I and II func-

tions, oxidative stress, methylation path-

way capability and glutathione levels

may all be evaluated in the laboratory:

Hepatic Detox Profile DNA Oxidative Damage Assay Methylation Profile; plasma Glutathione;

erythrocytes

A Functional Approach

to Neurotransmission

While not every neurological dys-

function may be completely reversed by

dietary changes, detoxification and the

nutritional support of biochemical en-

zyme pathways, a great many obstacles

to optimum function may be removed

by these therapies. Bredesen (2014) in

a pilot study with ten patients suffering

from Alzheimer’s and other types of de-

mentia, memory and cognitive dysfunc-

tions, has outlined a functional approach

that may slow neurodegeneration and

minimize oxidative stress in the brain.

Eight of the ten subjects improved suffi-

ciently to return to work or kept work-

ing with improved performance. The re-

sults are suggestive that the early stages

of cognitive decline may be exacerbated

by metabolic dysregulation. Bredesen

suggests that the basic tenets of the in-

dividualized programs may be used to

minimize metabolic dysregulation, in-

flammation and oxidative stress that

may contribute to neurodegeneration

and neurological symptoms; the need

for many of the suggested interventions

may be evaluated in the laboratory:

Elimination of simple carbohydrates

to minimize inflammation and

insulin resistance

Metabolomic Profile

Fast 12 hours each night, including

3 hours prior to bedtime to reduce

insulin levels and decrease amyloid-β

formation

Exercise 30-60 minutes 4-6 days

weekly

Normalize homocysteine levels

Plasma Methylation Profile

DNA Methylation Pathway

Maintain serum B12 > 500

Normalize inflammatory biomarkers

with anti-inflammatory diet,

curcumin, omega-3 fatty acids

Fatty Acids; Erythrocytes

Normalize and optimize thyroid and

other hormone levels

Thyroid Profile

Promote gastrointestinal health;

optimize digestion and absorption;

eliminate inflammation and

minimize autoimmunity;

promote health of gastrointestinal

microbiome

Comprehensive Stool Analysis

Intestinal Permeability