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114

 Functional Assessment of Urinary Neuro-biogenic Amines—A COMPREHENSIVE GUIDE

SNP has been associated with

increased familial susceptibility

to schizophrenia in those of

European or African-American

ancestry

TAAR8

Expressed in the amygdala of the

brain and in leukocytes, kidneys

TAAR9

Expressed in pituitary and in

leukocytes, kidney and skeletal

muscle

Trace amines may activate sigma re-

ceptors and modulate potassium and

calcium channels (in vitro); altering the

level of ions inside neurons may change

their action potential and firing rate.

Consider:

Selenium status

( RBC Elements )

Glutathione status

( Glutathione; erythrocytes )

Oxidative stress

( DNA Oxidative Damage Assay/8-OHdG )

Methylation pathway activity

( Plasma Methylation Profile

,

DNA Methylation Pathway )

References:

Berry, M.D. (2007)

The Potential of Trace Amines and Their

Receptors for Treating Neurological and

Psychiatric Diseases

Reviews on Recent Clinical Trials

, 2007, 2,

3-19

Berry, Mark D. (2004)

Mammalian central nervous system trace

amines. Pharmacologic amphetamines,

physiologic neuromodulators.

Journal of Neurochemistry

, Volume 90, Issue

2, pages 257–271, July 2004

Goldstein, David S. (2008)

Genotype and Vascular Phenotype Linked

by Catecholamine Systems

Circulation

vol. 117 (4) p. 458-461

Haduch, Anna; Bromek, Ewa; Daniel,

Władysława A (2013)

Role of brain cytochrome P450 (CYP2D)

in the metabolism of monoaminergic

neurotransmitters.

Pharmacological reports : PR

vol. 65 (6) p.

1519-28

Ledonne, Ada; Berretta, Nicola; Davoli,

Alessandro; Rizzo, Giada Ricciardo;

Bernardi, Giorgio et al. (2011)

Electrophysiological effects of trace amines

on mesencephalic dopaminergic neurons.

Frontiers in systems neuroscience

vol. 5 p. 56

Miller, Gregory M (2011)

The emerging role of trace amine-associated

receptor 1 in the functional regulation of

monoamine transporters and dopaminer-

gic activity.

Journal of neurochemistry

vol. 116 (2) p.

164-76

Narang, Deepak; Tomlinson, Sara; Holt,

Andrew; Darrell D. Mousseau, Glen B.

Baker, DSc, FCAHS (2011)

Trace amines and their relevance to psychia-

try and neurology: a brief overview

Bulletin of Clinical Psychopharmacology

vol.

21 (1) p. 73-79

Goldstein, David S. (2008)

Genotype and Vascular Phenotype Linked

by Catecholamine Systems

Circulation

vol. 117 (4) p. 458-461

Zucchi, R; Chiellini, G; Scanlan, T S; Grandy,

D K (2006)

Trace amine-associated receptors and their

ligands.

British journal of pharmacology

vol. 149 (8)

p. 967-78