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Functional Assessment of Urinary Neuro-biogenic Amines—A COMPREHENSIVE GUIDE 


Endozepines are nonbenzodiazepine,

nonprotein molecules produced within

the body. In vitro studies indicate that

endozepines secreted from astroglia

may bind to GABA-A receptors and act

like benzodiazepines on the receptors.

GABA signaling may also be modified

by the activity of the diazepam binding

inhibitor (DBI), a protein which may

displace endozepines and benzodiaze-

pines from GABA-A receptor binding

sites (in vitro studies).


Assess dysbiosis

( Comprehensive Stool Analysis )

Zinc status

( RBC Elements )

Calcium and potassium status

( Serum Elements )


Brambilla, P; Perez, J; Barale, F; Schettini, G;

Soares, J C (2003)

GABAergic dysfunction in mood disorders

Nature Publishing Group

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Chalifoux, Jason R; Carter, Adam G (2011)

GABAB receptor modulation of synaptic


Current opinion in neurobiology

vol. 21 (2) p.


Christian, Catherine A.; Huguenard, John R.


Astrocytes potentiate GABAergic transmis-

sion in the thalamic reticular nucleus via

endozepine signaling


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gut microbiome on mouse metabolic


Molecular Systems Biology

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Davies, Martin (2003)

The role of GABAA receptors in mediating

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Neuropsychopharmacology: The Fifth

Generation of Progress

Davis, et al.

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A Role of GABA Analogues in the

Treatment of Neurological Diseases

Current Medicinal Chemistry

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Gonzalez-Burgos, Guillermo; Fish, Kenneth

N; Lewis, David A (2011)

GABA neuron alterations, cortical circuit

dysfunction and cognitive deficits in


Neural plasticity

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Hettema, J M; An, S S; Neale, M C; Bukszar,

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Hyland, Niall P; Cryan, John F (2010)

A Gut Feeling about GABA: Focus on

GABA(B) Receptors.

Frontiers in pharmacology

vol. 1 p. 124

Jayakrishnan, Bindu; Hoke, David E;

Langendorf, Christopher G; Buckle,

Ashley M; Rowley, Merrill J (2011)

An analysis of the cross-reactivity of auto-

antibodies to GAD65 and GAD67 in


PloS one

vol. 6 (4) p. e18411

Kim, Kyung-Jin; Pearl, Phillip L; Jensen,

Kimmo; Snead, O Carter; Malaspina,

Patrizia et al. (2011)

Succinic semialdehyde dehydrogenase:

biochemical-molecular-clinical disease