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96

 Functional Assessment of Urinary Neuro-biogenic Amines—A COMPREHENSIVE GUIDE

Nonsense mutation may

contribute to some cases of

schizophrenia

TAAR5

Function and ligand unknown in

humans

TAAR6

Expressed in the amygdala of the

brain and in leukocytes, kidneys

SNP has been associated with

increased familial susceptibility

to schizophrenia with European

or African-American ancestry

TAAR8

Expressed in the amygdala of the

brain and in leukocytes, kidneys

TAAR9

Expressed in pituitary and in

leukocytes, kidney and skeletal

muscle

Trace amines may activate sigma re-

ceptors and modulate cellular potassium

and calcium channels (in vitro); alter-

ing the level of ions inside neurons may

change their action potential and firing

rate.

Consider:

Selenium status

( RBC Elements )

Glutathione status

( Glutathione; erythrocytes )

Oxidative stress

( DNA Oxidative Damage Assay/8-OHdG )

References:

Anwar, M A; Ford, W R; Broadley, K J;

Herbert, A A (2012)

Vasoconstrictor and vasodilator responses to

tryptamine of rat-isolated perfused mes-

entery: comparison with tyramine and

β-phenylethylamine.

British journal of pharmacology

vol. 165 (7)

p. 2191-202

Babusyte, Agne; Kotthoff, Matthias; Fiedler,

Julia; Krautwurst, Dietmar (2013)

Biogenic amines activate blood leukocytes

via trace amine-associated receptors

TAAR1 and TAAR2

J. Leukoc. Biol.

vol. 93 (3) p. 387-394

Mark D Berry, Mithila R Shitut (2013)

Membrane permeability of trace amines:

Evidence for a regulated, activity-depen-

dent, non-exocytotic, synaptic release.

Synapse

(New York, N.Y.)

Berry, M.D. (2007)

The Potential of Trace Amines and Their

Receptors for Treating Neurological and

Psychiatric Diseases

Reviews on Recent Clinical Trials

, 2007, 2,

3-19

Berry, Mark D. (2004)

Mammalian central nervous system trace

amines. Pharmacologic amphetamines,

physiologic neuromodulators.

Journal of Neurochemistry

Volume 90, Issue

2, pages 257–271, July 2004

Ledonne, Ada; Berretta, Nicola; Davoli,

Alessandro; Rizzo, Giada Ricciardo;

Bernardi, Giorgio et al. (2011)

Electrophysiological effects of trace amines

on mesencephalic dopaminergic neurons.

Frontiers in systems neuroscience

vol. 5 p. 56

Miller, Gregory M (2011)

The emerging role of trace amine-associated

receptor 1 in the functional regulation of

monoamine transporters and dopaminer-

gic activity.

Journal of Neurochemistry

vol. 116 (2) p.

164-76

Narang, Deepak; Tomlinson, Sara; Holt,

Andrew; Darrell D. Mousseau, Glen B.

Baker, DSc, FCAHS (2011)

Trace amines and their relevance to psychia-

try and neurology: a brief overview.